RNA Interference Directs Innate Immunity Against Viruses in Adult Drosophila
نویسندگان
چکیده
منابع مشابه
RNA interference directs innate immunity against viruses in adult Drosophila.
Innate immunity against bacterial and fungal pathogens is mediated by Toll and immune deficiency (Imd) pathways, but little is known about the antiviral response in Drosophila. Here, we demonstrate that an RNA interference pathway protects adult flies from infection by two evolutionarily diverse viruses. Our work also describes a molecular framework for the viral immunity, in which viral double...
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BACKGROUND The introduction of double-stranded RNA (dsRNA) can selectively interfere with gene expression in a wide variety of organisms, providing an ideal approach for functional genomics. Although this method has been used in Drosophila, it has been limited to studies of embryonic gene function. Only inefficient effects have been seen at later stages of development. RESULTS When expressed ...
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147 RNA interference (RNAi) is emerging as a new strategy to selectively shut off the post-transcriptional expression of mRNA. This evolutionarily maintained mechanism has been detected from yeast to mammalian cells. Rapid, inexpensive and selective silencing of a gene product in complex biological systems obviously has opened new avenues in fields of virology, cancer research, genetic disorder...
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ژورنال
عنوان ژورنال: Science
سال: 2006
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.1125694